EBV ImmuneSelect Peptide Pool Premium

Description

The EBV peptide pool contains 44 peptides (8-21mer) from Human herpesvirus 4 (Epstein Barr virus), derived from the following protein

• BARF1 protein
• BZLF1
• DNA polymerase catalytic subunit
• EBNA-1 (Epstein-Barr nuclear antigen 1)
• EBNA-2
• EBNA-3A
• EBNA-3B
• EBNA-6
• Glycoprotein GP110 precursor (MTP, p140)
• Large tegument protein deneddylase
• LMP1 (Latent membrane protein 1)
• LMP2A/B
• Envelope membrane glycoprotein GP350
• Transcription activator BRLF1

The peptide sequences are a mixture of MHC class–I & MHC class–II epitopes.  The purity of each peptide is ≥90% (HPLC-MS).

Application

The in-vitro stimulation of Peripheral Blood Mononuclear Cells (PBMCs) with EBV ImmuneSelect Peptide Pool activates memory T cells specific to the virus, leading to cytokine secretion and the increased expression of specific surface markers.